CytoDyn Announces Publication of Peer-Reviewed Article, “Suppression of Human and Simian Immunodeficiency Virus Replication with the CCR5-Specific Antibody Leronlimab in Two Species”
VANCOUVER, Wash., April 12, 2022 (GLOBE NEWSWIRE) — CytoDyn Inc. (OTCQB: CYDY) (“CytoDyn” or the “Company”), a late-stage biotechnology company developing leronlimab, a CCR5 antagonist with the potential for therapeutic indications, today announced the publication of a peer-reviewed research paper titled “Suppression of Human and Simian Immunodeficiency Virus Replication with the CCR5-Specific Antibody Leronlimab in Two Species” in the open access journal PLOS Pathogens.
The study followed five HIV-positive human participants who, after successfully transitioning to once-weekly subcutaneous leronlimab, discontinued their previous daily regimens of oral antiretroviral therapy. These five participants were from an extension study, consisting of virologically suppressed patients in a previous leronlimab study. Of the ten patients enrolled in the extension study, four people experienced viral rebound and discontinued leronlimab monotherapy, and one person withdrew, leaving five long-term participants. All five long-term participants successfully maintained HIV suppression via leronlimab monotherapy for more than seven years, with no evidence of viral escape. Importantly, these five participants on leronlimab monotherapy had a higher frequency (7.1%) of transient episodes of plasma viremia, called viral blips, than those on combined oral antiretroviral regimens (2.0%). . To monitor the anatomical penetrance of leronlimab, rhesus macaques acutely infected with simian human immunodeficiency virus (SHIV) were treated with high intravenous doses of leronlimab for 12 weeks. Leronlimab treatment reduced SHIV viral loads 10,000-fold, and leronlimab was found in all anatomical compartments analyzed, including mucosal and lymphatic tissues, sites of early viral replication after transmission and latency, respectively.
Jonah Sacha, Ph.D., the study’s lead author, who is scientific advisor to CytoDyn and a professor at Oregon Health & Science University, said, “To our knowledge, these data represent the longest administration of monoclonal antibody monotherapy for HIV in people with Date.”
CytoDyn is a clinical-stage biotechnology company focused on the development and commercialization of leronlimab, an investigational humanized IgG4 monoclonal antibody (mAb) designed to bind to the CC chemokine receptor type 5 (CCR5), a protein surface of some immune systems. cells thought to play a role in many disease processes. CytoDyn is studying leronlimab in several therapeutic areas, including infectious diseases, cancer and autoimmune diseases.
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Cristina De Leon